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Old Vaquero, loose chambers

I picked up an old Vaquero in 45 colt, I like it fine, except for one thing, if I tip the muzzle up while cocking, the cartridges are loose enough to slide to the rear. This was not something i picked up on at the dealer's, because I was not loading any live ammo inside the shop. I have to remember to keep the muzzle level or down while cocking. Is this a defect, anything I should worry about, or just continue holding muzzle down while cocking? btw, I have a new sizing die on order, although I do not expect that to make much of a difference, especially since I have not had this problem on another Vaquero, or a S&W m25 I own. I am relatively new to single action revolvers.
Comments
So what happens when they slide to the rear? Does it lock the action or make it really hard to cock the pistol - then you might have an issue.
It could also be something in the guts of the pistol - try doing it on an empty cylinder. Lightly stoning the working surface edges will help.
That said. No matter how loose, unfired cartridges are in the cylinder. If the don't expand and hang up in the chambers, after firing. With standard factory ammo. Making extraction difficult. I wouldn't worry about it.
The 45 Colt, is a 19th Century black powder cartridge. Because of the legal liability, this presents to the manufacturers of modern commercial ammo. I wouldn't be worrying, about shooting any of the common over the counter commercial 45 Colt ammo. The exotic heavy bullet hunting loads. And red line hand loads, would be the ones. That would cause me sleepless nights.
I have an old model Vaquero with thousands of rounds down the pipe and never an issue. I’ll have to try cocking it with the barrel elevated next time but I have a feeling it’s a non issue.