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45 colt vaquero 300 grain load

looking for a hunting load for the old model vaquero. i have 300 grain speer jsp bullets and 2400, imr4227, or unique powder. my manuals don't list loads for the 300 grain bullets. any help on a decent load. thanks.
Comments
2400 starts at 14.3 and maxes out at 15.9...
IMR4227 starts at 17.9 and maxes out at 18.7...
No clue about the Unique.......
2400 starts at 14.3 and maxes out at 15.9...
IMR4227 starts at 17.9 and maxes out at 18.7...
No clue about the Unique.......
The 2400 load Mrbruce has given you is a good one, it goes all the way back to Elmer Keith.
W.D.
Like any load, it works for me, but reduce the load and then work up to it in your gun.